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Antigen‐Inorganic Hybrid Flowers‐Based Vaccines with Enhanced Room Temperature Stability and Effective Anticancer Immunity
Author(s) -
Liu Yijia,
Zhu Xianghui,
Lu Yan,
Wang Xiaoli,
Zhang Chuangnian,
Sun Hongfan,
Ma Guilei
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900660
Subject(s) - ovalbumin , antigen , internalization , pinocytosis , immune system , chemistry , immunology , microbiology and biotechnology , biology , endocytosis , biochemistry , cell
Particle‐based antigen carriers as adjuvants play an important role in vaccine development. Herein, an antigen‐inorganic hybrid flower‐like particle is developed as a novel vaccine carrier. Model antigen ovalbumin (OVA)‐copper (II) sulfate hybrid vaccines (OVA‐Cu‐HVs) are mildly and facilely constructed through a biomimetic mineralization process. OVA‐Cu‐HVs facilitate cellular uptake in antigen‐presenting cells and the internalization of OVA‐Cu‐HVs involves macropinocytosis‐mediated endocytosis. OVA‐Cu‐HVs can release OVA in a pH‐responsive behavior and promote cytosolic release of antigen to enhance antigen cross‐presentation. Immunization with OVA‐Cu‐HVs promotes the maturation of dendritic cells in draining lymph nodes, induces robust antigen‐specific T lymphocyte response, and inhibits tumor growth in vivo. In addition, OVA‐Cu‐HVs are efficacious after being stored for 4 weeks at room temperature and are expected to simplify vaccine storage and lower the cost of cold storage for transportation. Looking forward, OVA‐Cu‐HVs may hold strong potential to be as an effective vaccine delivery platform, which will facilitate the application of organic–inorganic hybrid flowers in biomedical areas.