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Interconnected Toroidal Hydrogels for Islet Encapsulation
Author(s) -
Ernst Alexander U.,
Wang LongHai,
Ma Minglin
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900423
Subject(s) - self healing hydrogels , materials science , islet , cell encapsulation , encapsulation (networking) , toroid , biomedical engineering , transplantation , nanotechnology , computer science , insulin , medicine , surgery , polymer chemistry , computer network , plasma , physics , quantum mechanics
Islet encapsulation and transplantation promises to improve upon current treatments for type 1 diabetes mellitus, though several limitations remain. Macroscale devices have been designed for in vivo transplantation and retrieval, but traditional geometries do not support clinically adequate mass transfer of nutrients to and insulin from the encapsulated tissue. Microcapsule technologies have improved mass transfer properties, but their clinical translation remains challenging as their complete retrieval is difficult, should the graft become a safety concern. Here, the design, characterization and testing of a novel encapsulation structure, comprised of elastomer‐reinforced interconnected toroidal hydrogels is reported. These donut‐shaped hydrogels feature a high surface area, higher than conventional spherical capsules of the same volume, bestowing suitable mass transport conditions, while allowing interconnection and reversible deformation for intraperitoneal implantation and retrieval. Diabetes correction up to 12 weeks and complete retrieval is achieved in a diabetic mouse model, providing a proof‐of‐concept for the potential application as a type 1 diabetes cell replacement therapy.