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One‐Pot Synthesis of Unsaturated Polyester Bioelastomer with Controllable Material Curing for Microscale Designs
Author(s) -
Davenport Huyer Locke,
Bannerman A. Dawn,
Wang Yufeng,
Savoji Houman,
KneeWalden Ericka J.,
Brissenden Amanda,
Yee Bess,
Shoaib Mohammad,
Bobicki Erin,
Amsden Brian G.,
Radisic Milica
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900245
Subject(s) - elastomer , materials science , polyester , microscale chemistry , curing (chemistry) , polymer , monomer , composite material , chemical engineering , nanotechnology , mathematics education , mathematics , engineering
Abstract Synthetic polyester elastomeric constructs have become increasingly important for a range of healthcare applications, due to tunable soft elastic properties that mimic those of human tissues. A number of these constructs require intricate mechanical design to achieve a tunable material with controllable curing. Here, the synthesis and characterization of poly(itaconate‐ co‐ citrate‐ co‐ octanediol) (PICO) is presented, which exhibits tunable formation of elastomeric networks through radical crosslinking of itaconate in the polymer backbone of viscous polyester gels. Through variation of reaction times and monomer molar composition, materials with modulation of a wide range of elasticity (36–1476 kPa) are generated, indicating the tunability of materials to specific elastomeric constructs. This correlated with measured rapid and controllable gelation times. As a proof of principle, scaffold support for cardiac tissue patches is developed, which presents visible tissue organization and viability with appropriate elastomeric support from PICO materials. These formulations present potential application in a range of healthcare applications with requirement for elastomeric support with controllable, rapid gelation under mild conditions.