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Magnetically Actuated Degradable Microrobots for Actively Controlled Drug Release and Hyperthermia Therapy
Author(s) -
Park Jongeon,
Jin Chaewon,
Lee Seungmin,
Kim JinYoung,
Choi Hongsoo
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900213
Subject(s) - hyperthermia , materials science , ethylene glycol , drug delivery , biomedical engineering , magnetic nanoparticles , nanotechnology , viability assay , magnetic hyperthermia , nanoparticle , biophysics , cell , chemistry , medicine , biochemistry , organic chemistry , biology
Microrobots facilitate targeted therapy due to their small size, minimal invasiveness, and precise wireless control. A degradable hyperthermia microrobot (DHM) with a 3D helical structure is developed, enabling actively controlled drug delivery, release, and hyperthermia therapy. The microrobot is made of poly(ethylene glycol) diacrylate (PEGDA) and pentaerythritol triacrylate (PETA) and contains magnetic Fe 3 O 4 nanoparticles (MNPs) and 5‐fluorouracil (5‐FU). Its locomotion is remotely and precisely controlled by a rotating magnetic field (RMF) generated by an electromagnetic actuation system. Drug‐free DHMs reduce the viability of cancer cells by elevating the temperature under an alternating magnetic field (AMF), a hyperthermic effect. 5‐FU is released from the proposed DHMs in normal‐, high‐burst‐, and constant‐release modes, controlled by the AMF. Finally, actively controlled drug release from the DHMs in normal‐ and high‐burst‐release mode results in a reduction in cell viability. The reduction in cell viability is of greater magnitude in high‐burst‐ than in normal‐release mode. In summary, biodegradable DHMs have potential for actively controlled drug release and hyperthermia therapy.