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Optical Pacing of Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Mediated by a Conjugated Polymer Interface
Author(s) -
Lodola Francesco,
Vurro Vito,
Crasto Silvia,
Di Pasquale Elisa,
Lanzani Guglielmo
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900198
Subject(s) - photostimulation , materials science , cardiac muscle , induced pluripotent stem cell , photothermal therapy , biophysics , coupling (piping) , skeletal muscle , cardiac cell , biomedical engineering , nanotechnology , chemistry , microbiology and biotechnology , neuroscience , biology , anatomy , medicine , biochemistry , embryonic stem cell , metallurgy , gene
The use of light for triggering skeletal and cardiac muscles allows lower invasiveness higher selectivity and unprecedented possibility to target individual cells or even subcellular compartments in a temporally and spatially precise manner. Because cells are in general transparent, this requires the development of suitable interfaces that bestow light sensitivity to living matter. In the present work, successfully demonstrated is the use of conjugated polymer films as transducer to optically enhance the contraction rate of a human and patient‐specific cardiac in vitro cell model. By different experimental approaches, the coupling mechanism to the photothermal effect is assigned. This work extends the range of application of the polymer‐mediated cell photostimulation phenomenon to cardiac muscle cells, opening up possible applications in cardiac therapy and for implementation of in vitro studies.