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Photo‐Fenton‐like Metal–Protein Self‐Assemblies as Multifunctional Tumor Theranostic Agent
Author(s) -
Li Tianliang,
Zhou Jia,
Wang Lirui,
Zhang Hanfu,
Song Cunfeng,
de la Fuente Jesús M.,
Pan Yunxiang,
Song Jie,
Zhang Chunlei,
Cui Daxiang
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900192
Subject(s) - photodynamic therapy , photosensitizer , photothermal therapy , indocyanine green , reactive oxygen species , doxorubicin , catalase , copper , metal ions in aqueous solution , materials science , chemistry , biophysics , cytotoxicity , fluorescence , glutathione , nanotechnology , photochemistry , in vitro , metal , oxidative stress , biochemistry , organic chemistry , enzyme , medicine , surgery , physics , chemotherapy , quantum mechanics , biology
Emerging Fenton‐like activity of copper ions has inspired great exploration for tumor microenvironment‐activated tumor therapy due to the toxic ·OH production for chemodynamic therapy and extra oxygen generation for photodynamic therapy (PDT). Still, the ·OH produced by copper ions is not satisfied even when copper ions are placed in a low pH environment (pH ≈ 5.0). To amplify its Fenton‐like activity, in this work, one kind of Cu 2+ –protein self‐assemblies (C‐m‐ABs) loaded with photosensitizer indocyanine green (ICG) is constructed, which can catalyze H 2 O 2 generating more amounts of ·OH under light irradiation once Cu 2+ is reduced to Cu + by glutathione. Such fantastic phenomena confirms that C‐m‐ABs can act as a photo‐Fenton‐like agent. Furthermore, C‐m‐ABs can dramatically accelerate O 2 generation (catalase activity) to enhance the PDT of ICG. After loading with the anticancer drug doxorubicin, C‐m‐ABs are further self‐assembled into novel nanobelts, which simultaneously exhibit superior photo‐heat conversion effects, enhanced r1 relaxation (21.416 s −1 m m −1 ) and stimuli‐responsive drug release behaviors. High cytotoxicity in vitro, effective tumor accumulation capacity observed by fluorescence/photoacoustic/magnetic resonance imaging, and enhanced chemo‐/photodynamic/photothermal therapeutic performance are achieved. Based on these results, a photo‐Fenton‐like metal–protein self‐assemblies demonstrate great potential for tumor theranostics.