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Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres
Author(s) -
Chen Lin,
Ma Xiaobo,
Dang Meng,
Dong Heng,
Hu Hongming,
Su Xiaodan,
Liu Wenfei,
Wang Qing,
Mou Yongbin,
Teng Zhaogang
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900039
Subject(s) - cytotoxic t cell , immunotherapy , materials science , macrophage polarization , cancer research , t cell , cd8 , immune system , macrophage , microbiology and biotechnology , chemistry , in vitro , biology , immunology , biochemistry
Nanomaterial‐based immunotherapy stimulating T cell activation or tumor‐associated macrophage (TAM) conversion holds great promise for promoting tumor suppression. Herein, a novel nanoplatform, iron oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs), is prepared for the first time to simultaneously activate cytotoxic T cells and polarize macrophages for potent tumor immunotherapy. The IO‐LPMONs have large mesopores (6.3 nm) and inorganic–organic hybrid shells, which contribute to a high payload (500 µg mg −1 ) of the antigen ovalbumin (OVA). The IO‐LPMONs effectively deliver OVA to dendritic cells (DCs) and activate DCs. Subsequently, high activation of both CD4 + and CD8 + effector antigen‐specific T cells is achieved for powerful antitumor effects. Moreover, the IO‐LPMONs also act as an immune modulator to polarize TAMs from an immunosuppressive M2 to a tumor‐killing M1 phenotype, which induces efficient apoptosis of tumor cells. The combined T cell activation and macrophage polarization strategy based on the IO‐LPMONs elicits remarkable combined antitumor effects in vivo, showing great promise for tumor treatment.