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Atherosclerosis Treatment with Stimuli‐Responsive Nanoagents: Recent Advances and Future Perspectives
Author(s) -
Maruf Ali,
Wang Yi,
Yin Tieyin,
Huang Junli,
Wang Nan,
Durkan Colm,
Tan Youhua,
Wu Wei,
Wang Guixue
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900036
Subject(s) - nanoengineering , nanotechnology , computer science , materials science
Abstract Atherosclerosis is the root of approximately one‐third of global mortalities. Nanotechnology exhibits splendid prospects to combat atherosclerosis at the molecular level by engineering smart nanoagents with versatile functionalizations. Significant advances in nanoengineering enable nanoagents to autonomously navigate in the bloodstream, escape from biological barriers, and assemble with their nanocohort at the targeted lesion. The assembly of nanoagents with endogenous and exogenous stimuli breaks down their shells, facilitates intracellular delivery, releases their cargo to kill the corrupt cells, and gives imaging reports. All these improvements pave the way toward personalized medicine for atherosclerosis. This review systematically summarizes the recent advances in stimuli‐responsive nanoagents for atherosclerosis management and its progress in clinical trials.