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Polypill: Programming of Multicomponent Temporal Release Profiles in 3D Printed Polypills via Core–Shell, Multilayer, and Gradient Concentration Profiles (Adv. Healthcare Mater. 16/2018)
Author(s) -
Haring Alexander P.,
Tong Yuxin,
Halper Justin,
Johnson Blake N.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201870066
Subject(s) - polypill , extrusion , materials science , 3d printing , shell (structure) , core (optical fiber) , biomedical engineering , nanotechnology , computer science , chemical engineering , composite material , chemistry , engineering , biochemistry , aspirin
In article 1800213 , Blake N. Johnson and co‐workers demonstrate how extrusion‐based 3D printing enables the programming of delayed, pulsed, and continuous temporal release profiles in multi‐component oral tablets, also known as polypills, via the use of core‐shell, multilayer, and gradient spatial distributions of actives, respectively. Mass transfer processes are considered for design, quality, and performance of additively‐manufactured pharmaceutical systems.