Premium
Supramolecular Nanotherapeutics: Turning Toxicants into Safe Therapeutic Drugs: Cytolytic Peptide−Photosensitizer Assemblies for Optimized In Vivo Delivery of Melittin (Adv. Healthcare Mater. 16/2018)
Author(s) -
Jia HaoRan,
Zhu YaXuan,
Xu KeFei,
Wu FuGen
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201870063
Subject(s) - melittin , photosensitizer , in vivo , photodynamic therapy , peptide , materials science , hyaluronic acid , phototoxicity , cancer research , nanotechnology , chemistry , medicine , in vitro , biochemistry , biology , microbiology and biotechnology , organic chemistry , anatomy
In article number 1800380 , Fu‐Gen Wu and co‐workers illustrate a novel supramolecular strategy that successfully turns cytolytic melittin, a peptide component in bee venom, into a safe and tumor‐targeting therapeutic nanodrug. The nanostructure is assembled by melittin, photosensitizer chlorin e6 (Ce6), and hyaluronic acid, which exhibits reduced hemolytic activity, laser‐enhanced tumor penetration, and efficient tumor ablation by chemo‐photodynamic dual therapy.