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Antivirulence Therapy: Broad‐Spectrum Neutralization of Pore‐Forming Toxins with Human Erythrocyte Membrane‐Coated Nanosponges (Adv. Healthcare Mater. 13/2018)
Author(s) -
Chen Yijie,
Chen Mengchun,
Zhang Yue,
Lee Joo Hee,
Escajadillo Tamara,
Gong Hua,
Fang Ronnie H.,
Gao Weiwei,
Nizet Victor,
Zhang Liangfang
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201870049
Subject(s) - listeria monocytogenes , staphylococcus aureus , microbiology and biotechnology , broad spectrum , in vivo , in vitro , virulence , bacteria , chemistry , biology , biochemistry , genetics , gene , combinatorial chemistry
In article 1701366 by Liangfang Zhang and co‐workers, human red blood cell (RBC) nanosponges are designed and demonstrated to concurrently absorb various types of different virulence factors including those from methicillin‐resistant Staphylococcus aureus , Listeria monocytogenes , and Group A Streptococcus . Toxins absorbed by the nanosponges are no longer able to damage healthy RBCs or other normal human cells both in vitro and in vivo.