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Multivalent Ligands: Integrin Clustering Matters: A Review of Biomaterials Functionalized with Multivalent Integrin‐Binding Ligands to Improve Cell Adhesion, Migration, Differentiation, Angiogenesis, and Biomedical Device Integration (Adv. Healthcare Mater. 12/2018)
Author(s) -
Karimi Fatemeh,
O'Connor Andrea J.,
Qiao Greg G.,
Heath Daniel E.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201870048
Subject(s) - integrin , adhesion , angiogenesis , cell adhesion , in vivo , microbiology and biotechnology , nanotechnology , in vitro , chemistry , materials science , cell , cancer research , biochemistry , biology , organic chemistry
Biomaterials functionalized with nano‐scale clusters of integrin‐binding ligands exhibit enhanced cell‐material interactions including higher adhesion rates, greater adhesion strength, increased proliferation, and better biomedical device integration in comparison to materials functionalized with randomly spaced ligands. The review in article 1701324 by Daniel E. Heath, Greg G. Qiao, and co‐workers focuses on the methodologies that have been developed in order to generate these materials as well as their improved in vitro and in vivo performance.