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Pre‐Metastatic Niche: Biomaterial Scaffolds as Pre‐metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment (Adv. Healthcare Mater. 10/2018)
Author(s) -
Aguado Brian A.,
Hartfield Rachel M.,
Bushnell Grace G.,
Decker Joseph T.,
Azarin Samira M.,
Nanavati Dhaval,
Schipma Matthew J.,
Rao Shreyas S.,
Oakes Robert S.,
Zhang Yining,
Jeruss Jacqueline S.,
Shea Lonnie D.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201870040
Subject(s) - biomaterial , niche , metastasis , cancer research , tumor microenvironment , in vivo , primary tumor , immune system , medicine , biology , tumor cells , immunology , cancer , biomedical engineering , microbiology and biotechnology , biochemistry
Biomaterial implants that mimic the premetastatic niche are shown to redirect immune and tumor cell populations in vivo. However, the systemic effects of premetastatic niche mimics on metastasis progression have yet to be characterized. In article 1700903 by Lonnie D. Shea and co‐workers, synthetic biomaterial implants are shown to systemically alter the primary tumor and the tumor microenvironment to promote an invasion‐suppressive phenotype. Cover art designed and produced by Stephen Alvey, University of Michigan, Department of Engineering.