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Macular Degeneration: Wet‐AMD on a Chip: Modeling Outer Blood‐Retinal Barrier In Vitro (Adv. Healthcare Mater. 2/2018)
Author(s) -
Chung Minhwan,
Lee Somin,
Lee Byung Joo,
Son Kyungmin,
Jeon Noo Li,
Kim Jeong Hun
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201870011
Subject(s) - barrier function , blood–retinal barrier , choroid , retinal pigment epithelium , tight junction , macular degeneration , retinal , in vitro , retina , monolayer , materials science , microbiology and biotechnology , anatomy , chemistry , ophthalmology , biology , medicine , neuroscience , nanotechnology , biochemistry , endocrinology , diabetic retinopathy , diabetes mellitus
In article number 1700028 , Noo Li Jeon, Jeong Hun Kim, and co‐workers describe a unique organotypic eye‐on‐a‐chip model that mimics the retinal pigment epithelium (RPE)–choroid complex in vitro. This model consists of an RPE monolayer and adjacent perfusable blood vessel network, which is supporting barrier function of the outer blood retinal barrier (oBRB). The intact barrier function of the RPE‐choroid complex is reconstituted while maintaining important structural features.