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Biomedical Applications of DNA‐Based Molecular Devices
Author(s) -
Liu Shaoli,
Jiang Qiao,
Wang Yuanning,
Ding Baoquan
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801658
Subject(s) - nanotechnology , dna , dna nanotechnology , drug delivery , computer science , materials science , biology , genetics
Strict Watson–Crick base pairing and availability by automated synthesis have allowed deoxyribonucleic acid (DNA) molecules to be used as engineerable building blocks for constructing versatile nanostructures. In recent decades, with the development of DNA nanotechnology, a range of DNA‐based dynamic molecular devices with sophisticated nanostructures have been designed and constructed. Featuring programmability and biocompatibility, the applications of DNA‐based nanodevices have been extensively focused on the interfaces of biological systems. This review summarizes the recent progress in the design of DNA devices exhibiting programmable functions for biomedical applications. In vitro and in vivo applications of DNA‐based nanodevices in cellular imaging and systemic drug delivery are highlighted. The challenges and open opportunities are also discussed.