Premium
Sunlight‐Driven Wearable and Robust Antibacterial Coatings with Water‐Soluble Cellulose‐Based Photosensitizers
Author(s) -
Jia Ruonan,
Tian Weiguo,
Bai Haotian,
Zhang Jinming,
Wang Shu,
Zhang Jun
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801591
Subject(s) - antibacterial activity , photosensitizer , cellulose , protoporphyrin ix , coating , chemistry , biopolymer , combinatorial chemistry , dissolution , materials science , bacteria , photodynamic therapy , chemical engineering , photochemistry , organic chemistry , polymer , genetics , engineering , biology
Abstract Herein, a simple, effective, and general strategy is demonstrated to obtain a water‐soluble and nontoxic cellulose‐based photosensitizer (CPS) with enhanced photodynamic antibacterial activity through introducing protoporphyrin IX (PpIX) and quaternary ammonium salt (QAS) groups onto the cellulose backbone. The synergistic effect of the anchoring and diluting effect of the cellulose backbone and the electrostatic repulsion between QAS groups effectively inhibit the π–π stacking of PpIX groups, thus the as‐prepared CPS exhibits markedly enhanced reactive oxygen species (ROS) yield. Meanwhile, the positively charged QAS groups endow the CPS with water‐solubility and a strong attractive force to bacteria. As a result, the CPS can rapidly and efficiently kill drug‐resistant bacteria strains, including E. coli and S. aureus , with a low light dose (2.4 J cm −2 ) and low concentration of PpIX groups (0.35 × 10 −6 m ). Benefiting from the excellent processability and formability, the CPS is readily applied as a sunlight‐driven wearable and robust antibacterial coating by a spray coating and later crosslinking procedure.