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A Novel Surface Enhanced Raman Catheter for Rapid Detection, Classification, and Grading of Oral Cancer
Author(s) -
Chundayil Madathil Girish,
Iyer Subramania,
Thankappan Krishnakumar,
Gowd G. Siddaramana,
Nair Shantikumar,
Koyakutty Manzoor
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801557
Subject(s) - grading (engineering) , catheter , materials science , leukoplakia , biomedical engineering , pathology , cancer , medicine , radiology , biology , ecology
Abstract Fabrication and testing of a novel nanostructured surface‐enhanced Raman catheter device is reported for rapid detection, classification, and grading of normal, premalignant, and malignant tissues with high sensitivity and accuracy. The sensor part of catheter is formed by a surface‐enhanced Raman scattering (SERS) substrate made up of leaf‐like TiO 2 nanostructures decorated with 30 nm sized Ag nanoparticles. The device is tested using a total of 37 patient samples wherein SERS signatures of oral tissues consisting of malignant oral squamous cell carcinoma (OSCC), verrucous carcinoma, premalignant leukoplakia, and disease‐free conditions are detected and classified with an accuracy of 97.24% within a short detection‐cum‐processing time of nearly 25–30 min per patient. Neoplastic grade changes detected using this device correlate strongly with conventional pathological data, enabling correct classification of tumors into three grades with an accuracy of 97.84% in OSCC. Thus, the potential of a SERS catheter device as a point‐of‐care pathological tool is shown for the rapid and accurate detection, classification, and grading of solid tumors.