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Optimized Bioactive Glass: the Quest for the Bony Graft
Author(s) -
Granel Henri,
Bossard Cédric,
Nucke Lisa,
Wauquier Fabien,
Rochefort Gael Y.,
Guicheux Jérôme,
Jallot Edouard,
Lao Jonathan,
Wittrant Yohann
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801542
Subject(s) - biomaterial , materials science , scaffold , bioactive glass , polymer , nanotechnology , brittleness , homogeneous , biomedical engineering , composite material , engineering , physics , thermodynamics
Technological advances have provided surgeons with a wide range of biomaterials. Yet improvements are still to be made, especially for large bone defect treatment. Biomaterial scaffolds represent a promising alternative to autologous bone grafts but in spite of the numerous studies carried out on this subject, no biomaterial scaffold is yet completely satisfying. Bioactive glass (BAG) presents many qualifying characteristics but they are brittle and their combination with a plastic polymer appears essential to overcome this drawback. Recent advances have allowed the synthesis of organic–inorganic hybrid scaffolds combining the osteogenic properties of BAG and the plastic characteristics of polymers. Such biomaterials can now be obtained at room temperature allowing organic doping of the glass/polymer network for a homogeneous delivery of the doping agent. Despite these new avenues, further studies are required to highlight the biological properties of these materials and particularly their behavior once implanted in vivo. This review focuses on BAG with a particular interest in their combination with polymers to form organic–inorganic hybrids for the design of innovative graft strategies.