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A Foreign Body Response‐on‐a‐Chip Platform
Author(s) -
Sharifi Fatemeh,
Htwe Su Su,
Righi Martina,
Liu Hua,
Pietralunga Anna,
YesilCeliktas Ozlem,
Maharjan Sushila,
Cha ByungHyun,
Shin Su Ryon,
Dokmeci Mehmet Remzi,
Vraihal Engin,
Ghaemmaghami Amir M.,
Khademhosseini Ali,
Zhang Yu Shrike
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801425
Subject(s) - self healing hydrogels , extracellular matrix , immune system , microbiology and biotechnology , implant , microfluidics , chemotaxis , inflammation , materials science , monocyte , biomedical engineering , nanotechnology , immunology , biology , medicine , receptor , surgery , polymer chemistry
Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR‐on‐a‐chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP‐1) from the extracellular matrix (ECM)‐like hydrogels in the bottom tissue chamber induces trans‐endothelial migration of circulating monocytes in the vascular channel toward the hydrogels, thus mimicking implant‐induced inflammation. Data using patient‐derived peripheral blood mononuclear cells further reveal inter‐patient differences in FBR, highlighting the potential of this platform for monitoring FBR in a personalized manner. The prototype FBROC platform provides an enabling strategy to interrogate FBR on various implants, including biomaterials and engineered tissue constructs, in a physiologically relevant and individual‐specific manner.