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Unraveling the Mechanobiology of the Immune System
Author(s) -
Kim JeongKi,
Shin Yu Jung,
Ha Leslie Jaesun,
Kim DeokHo,
Kim DongHwee
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801332
Subject(s) - mechanobiology , mechanosensation , immune system , context (archaeology) , biology , microbiology and biotechnology , homeostasis , neuroscience , immunology , paleontology , biochemistry , receptor , ion channel
Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.