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Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering
Author(s) -
Witzel IniIsabée,
Nasser Rasha,
GarciaSabaté Anna,
Sapudom Jiranuwat,
Ma Chao,
Chen Weiqiang,
Teo Jeremy C. M.
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801126
Subject(s) - immune system , biology , microbiology and biotechnology , antigen presentation , immunology , t cell
The immune microenvironment presents a diverse panel of cues that impacts immune cell migration, organization, differentiation, and the immune response. Uniquely, both the liquid and solid phases of every specific immune niche within the body play an important role in defining cellular functions in immunity at that particular location. The in vivo immune microenvironment consists of biomechanical and biochemical signals including their gradients, surface topography, dimensionality, modes of ligand presentation, and cell–cell interactions, and the ability to recreate these immune biointerfaces in vitro can provide valuable insights into the immune system. This manuscript reviews the critical roles played by different immune cells and surveys the current progress of model systems for reverse engineering of immune microenvironments with a focus on lymphoid tissues.