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Advancing Frontiers in Bone Bioprinting
Author(s) -
Ashammakhi Nureddin,
Hasan Anwarul,
Kaarela Outi,
Byambaa Batzaya,
Sheikhi Amir,
Gaharwar Akhilesh K.,
Khademhosseini Ali
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801048
Subject(s) - 3d bioprinting , nanotechnology , 3d printed , self healing hydrogels , materials science , computer science , biomedical engineering , tissue engineering , engineering , polymer chemistry
Three‐dimensional (3D) bioprinting of cell‐laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser‐assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. In this review, a critical overview of the recent literature on various types of bioinks used for bone bioprinting is presented. Major challenges, such as the vascularity, clinically relevant size, and mechanical properties of 3D printed structures, that need to be addressed to successfully use the technology in clinical settings, are discussed. Emerging approaches to solve these problems are reviewed, and future strategies to design customized 3D printed structures are proposed.