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Multimodal Cancer Theranosis Using Hyaluronate‐Conjugated Molybdenum Disulfide
Author(s) -
Shin MyeongHwan,
Park EunYeong,
Han Seulgi,
Jung Ho Sang,
Keum Do Hee,
Lee GeonHui,
Kim Taeyeon,
Kim Chulhong,
Kim Ki Su,
Yun Seok Hyun,
Hahn Sei Kwang
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201801036
Subject(s) - photothermal therapy , materials science , conjugated system , molybdenum disulfide , nanomaterials , conjugate , endocytosis , nanoprobe , fluorescence , photon upconversion , cancer cell , nanotechnology , biophysics , nanoparticle , luminescence , cancer , chemistry , optoelectronics , polymer , cell , optics , biochemistry , medicine , composite material , biology , metallurgy , physics , mathematics , mathematical analysis
Abstract Among various 2D nanomaterials, molybdenum disulfide (MoS 2 ) exhibits unique visible photoluminescence with high absorption at the near‐infrared (NIR) range. Despite these optical properties, the efforts to use MoS 2 nanomaterials for optical imaging and photothermal therapy are hampered by their instability and low intracellular delivery efficiency. Multifunctional MoS 2 conjugated with hyaluronate (HA) for cancer theranosis is reported herein. HA facilitates the delivery of MoS 2 to tumor cells by the HA‐receptor mediated endocytosis. In BALB/c nude mice inoculated with a colorectal cancer cell line of HCT116, HA‐MoS 2 conjugates appear to be accumulated in the primary tumor at a content more than that in the liver and kidney. The disulfide bonding between MoS 2 and thiolated HA seems to degrade in the cytoplasm, releasing MoS 2 sheets in stacks and enhancing luminescence efficiency. The HA‐MoS 2 conjugates are readily detected via photoacoustic imaging as well as upconversion and downconversion fluorescence imaging. With NIR light illumination, HA‐MoS 2 conjugates enable highly effective photothermal tumor ablation. All these results confirm the promising potential of HA‐MoS 2 conjugates for cancer theranosis.