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Biomedical Applications of Layer‐by‐Layer Self‐Assembly for Cell Encapsulation: Current Status and Future Perspectives
Author(s) -
Liu Tengfei,
Wang Ying,
Zhong Wen,
Li Bingyun,
Mequanint Kibret,
Luo Gaoxing,
Xing Malcolm
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800939
Subject(s) - encapsulation (networking) , cell encapsulation , nanotechnology , materials science , tissue engineering , computer science , engineering , biomedical engineering , computer network
Encapsulating living cells within multilayer functional shells is a crucial extension of cellular functions and a further development of cell surface engineering. In the last decade, cell encapsulation has been widely utilized in many cutting‐edge biomedical fields. Compared with other techniques for cell encapsulation, layer‐by‐layer (LbL) self‐assembly technology, due to the versatility and tunability to fabricate diverse multilayer shells with controllable compositions and structures, is considered as a promising approach for cell encapsulation. This review summarizes the state‐of‐the‐art and potential future biomedical applications of LbL cell encapsulation. First of all, a brief introduction to the LbL self‐assembly technique, including assembly mechanisms and technologies, is made. Next, different cell encapsulation strategies by LbL self‐assembly techniques are explained. Then, the biomedical applications of LbL cell encapsulation in cell‐based biosensors, cell transplantation, cell/molecule delivery, and tissue engineering, are highlighted. Finally, discussions on the current limitations and future perspectives of LbL cell encapsulation are also provided.