Premium
Gels without Vapor Pressure: Soft, Nonaqueous, and Solvent‐Free Supramolecular Biomaterials for Prospective Parenteral Drug Delivery Applications
Author(s) -
Tabet Anthony,
Wang Chun
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800908
Subject(s) - supramolecular chemistry , drug delivery , nanotechnology , materials science , biocompatible material , drug , soft materials , organic chemistry , chemistry , biomedical engineering , medicine , pharmacology , molecule
Abstract The engineering advantages of soft, nonaqueous, solvent‐free supramolecular materials have resulted in their emerging transition and adoption from a predominantly food, cosmetics, and paint industry‐driven technology to biocompatible matrices for parenteral drug delivery. Factors that have contributed to this trend are the drastic increase of hydrophobic and combination drugs in the pharmaceutical pipeline and the limitations of hydrated drug delivery materials with regard to poorly soluble drugs and biologics. This review highlights examples of nonaqueous, soft supramolecular materials, illustrates molecular engineering principles that may give rise to novel structures and unique properties, and explores emerging opportunities of application of these materials in parenteral drug delivery.