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Mixed and Matched Metallo‐Nanotexaphyrin for Customizable Biomedical Imaging
Author(s) -
Keca Joseph M.,
Valic Michael S.,
Cheng Miffy H. Y.,
Jiang Wenlei,
Overchuk Marta,
Chen Juan,
Zheng Gang
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800857
Subject(s) - magnetic resonance imaging , materials science , nanoparticle , nanotechnology , chelation , emission computed tomography , in vivo , combinatorial chemistry , biomedical engineering , chemistry , positron emission tomography , nuclear medicine , medicine , radiology , microbiology and biotechnology , biology , metallurgy
The discovery and synthesis of multifunctional organic building blocks for nanoparticles have remained challenging. Texaphyrin macrocycles are multifunctional, all‐organic compounds that possess versatile metal‐chelation capabilities and unique theranostics properties for biomedical applications. Unfortunately, there are significant difficulties associated with the synthesis of texaphyrin‐based subunits capable of forming nanoparticles. Herein, the detailed synthesis of a texaphyrin‐phospholipid building block is reported via a key 1,2‐dinitrophenyl‐phospholipid intermediate, along with stable chelation of two clinically relevant metal ions into texaphyrin‐lipid without compromising their self‐assembly into texaphyrin nanoparticles or nanotexaphyrin. A postinsertion methodology to quantitatively insert a variety of metal‐ions into preformed nanotexaphyrins is developed and employed to synthesize a structurally stable, mixed 111 indium‐manganese‐nanotexaphyrin for dual modal single‐photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). In vivo dual SPECT/MRI imaging of 111 In‐Mn‐nanotexaphyrins in an orthotopic prostatic PC3 mouse model demonstrates complementary signal enhancement in the tumor with both modalities at 22 h post intravenous administration. This result highlights the utility of hybrid metallo‐nanotexaphyrins to achieve sensitive and accurate detection of tumors by accommodating multiple imaging modalities. The power of this mixed and matched metallo‐nanotexaphyrin strategy can be unleashed to allow a diverse range of multifunctional biomedical imaging.