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Gold Nanoparticles with Antibiotic‐Metallopolymers toward Broad‐Spectrum Antibacterial Effects
Author(s) -
Yang Peng,
Pageni Parasmani,
Rahman Md Anisur,
Bam Marpe,
Zhu Tianyu,
Chen Yung Pin,
Nagarkatti Mitzi,
Decho Alan W.,
Tang Chuanbing
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800854
Subject(s) - antibiotics , bacteria , antimicrobial , broad spectrum , colloidal gold , nanoparticle , nanotechnology , antibacterial activity , pathogenic bacteria , materials science , microbiology and biotechnology , chemistry , combinatorial chemistry , biology , genetics
Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug‐resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer‐antibiotic bioconjugates on gold nanoparticles is developed as an antibacterial agent to fight against different bacterial strains. Thus, these nanoparticle conjugates combine various components in one system to display enhanced bactericidal efficacy, in which small sized nanoparticles provide high surface area for bacteria to contact, cationic metallopolymers interact with the negatively charged bacterial membranes, and the β‐lactam antibiotics' sterilzation capabilities are improved via evading intracellular enzymolysis by β‐lactamase. This nanoparticle‐based antibiotic‐metallopolymer system exhibits an excellent broad‐spectrum antibacterial effect, particularly for Gram‐negative bacteria, due to the synergistic effect of multicomponents on the interaction with bacteria.