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Sub‐Micrometer Au@PDA‐ 125 I Particles as Theranostic Embolism Beads for Radiosensitization and SPECT/CT Monitoring
Author(s) -
Sun Gaofeng,
Wang Tao,
Li Xiao,
Li Danni,
Peng Ye,
Wang Xiaoke,
Jia Guorong,
Su Weiwei,
Cheng Chao,
Yang Jian,
Zuo Changjing
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800375
Subject(s) - nuclear medicine , materials science , irradiation , radiochemistry , radiation therapy , single photon emission computed tomography , biomedical engineering , chemistry , medicine , radiology , physics , nuclear physics
Au nanoparticles (3.8 ± 0.6 nm) are assembled to sub‐micrometer Au particles (186.3 ± 20.4 nm) and covered with adhesive polydopamine (PDA) as embolism beads (198.8 ± 23.2 nm). Radioactive iodine‐125 is labeled to Au@PDA to introduce the function of intra‐irradiation. For the therapeutic effects of Au@PDA‐ 125 I, Au particles sensitize the radiation to MHCC97H hepatoma cells and tumor‐bearing mice. At the cellular level, after being treated with a relatively low‐dose (5 Gy) γ‐ray, Au‐sensitized radiotherapy (RT) leads to an immediate increase of intracellular reactive oxygen species, accompanying with an increase of cell apoptosis. Due to the intra‐irradiation, self‐healing of RT‐leaded DNA double‐strand breakage is suppressed, inducing a further increase of cell apoptosis after RT treatment. Likewise, 3 cycles of sensitized RT leads to a valid control of tumor volume growth, but Au@PDA‐ 125 I has no harm or radioactive residual on or in the radiosensitive organs, including the thyroid, heart, lungs, liver, and spleen. Additionally, photons emitted from 125 I and high X‐ray absorption of the Au element makes the beads suitable for single photon emission computed tomography/computed tomography (SPECT/CT) imaging. Therefore, as theranostic embolism beads, Au@PDA‐ 125 I can both enhance the therapeutic effects of external RT, and provide a real‐time SPECT/CT monitoring of therapeutic time window.