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Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery
Author(s) -
Hu Shuang,
Kang Homan,
Baek Yoonji,
El Fakhri Georges,
Kuang Anren,
Choi Hak Soo
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800066
Subject(s) - medicine , neuronavigation , intraoperative mri , magnetic resonance imaging , palpation , brain tumor , neurosurgery , radiology , resection margin , brain tissue , resection , surgery , pathology , interventional magnetic resonance imaging , biomedical engineering
The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue. Moreover, malignant brain tumors are even more difficult to distinguish from normal brain tissue, and resecting noncancerous tissue may create neurological defects after surgery. To optimize the resection margin in brain tumors, a variety of intraoperative guidance techniques are developed, such as neuronavigation, magnetic resonance imaging, ultrasound, Raman spectroscopy, and optical fluorescence imaging. When combined with appropriate contrast agents, optical fluorescence imaging can provide the neurosurgeon real‐time image guidance to improve resection completeness and to decrease surgical complications.