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Nanoscaled Metal‐Organic Frameworks for Biosensing, Imaging, and Cancer Therapy
Author(s) -
Zhou Jingrong,
Tian Gan,
Zeng Lijuan,
Song Xueer,
Bian Xiuwu
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201800022
Subject(s) - nanotechnology , materials science , cancer therapy , nanomedicine , metal organic framework , drug delivery , biosensor , cancer imaging , cancer , nanoparticle , medicine , chemistry , organic chemistry , adsorption
Owing to the progressive development of metal‐organic frameworks (MOFs) synthetic processes and their unique characters associated with the excellent performance‐selectable composition, tunable pore scale, large surface area, and good thermal stability, MOFs have captured the interest and the imagination of an increasing number of scientists working in different fields. In the area of biomedical applications, MOFs are especially involved in sensing, molecular imaging, and drug delivery, with strong contributions to the whole nanomedicine area. Recently, these materials have been scaled down to nanometer sizes with the advancement of chemical synthesis gradually reaching an adjustable level. This review mainly discusses and summarizes the general synthesis, properties, and biomedical applications of nanoscaled MOFs and their composites in biosensing, imaging, and cancer therapy within the latest three years. The remaining challenges and future opportunities in this field, in terms of processing techniques, maximizing composite properties, and prospects for clinical applications, are also indicated.