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Mesoporous Silica Nanoparticles: Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles (Adv. Healthcare Mater. 20/2017)
Author(s) -
Yang Jian,
Tu Jing,
Lamers Gerda E. M.,
Olsthoorn René C. L.,
Kros Alexander
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201770104
Subject(s) - mesoporous silica , endocytosis , lipid bilayer , materials science , nanoparticle , lipid bilayer fusion , nanotechnology , membrane , bilayer , mesoporous material , vesicle fusion , biophysics , vesicle , chemistry , cell , biochemistry , biology , synaptic vesicle , catalysis
In article number 1700759 , Alexander Kros and co‐workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled‐coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid‐coated MSNs. In this manner proteins can be efficiently delivered into the cytoplasm of cells.