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Angiogenesis: Affinity‐Immobilization of VEGF on Laminin Porous Sponge Enhances Angiogenesis in the Ischemic Brain (Adv. Healthcare Mater. 11/2017)
Author(s) -
Oshikawa Mio,
Okada Kei,
Kaneko Naoko,
Sawamoto Kazunobu,
Ajioka Itsuki
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201770057
Subject(s) - angiogenesis , sponge , neovascularization , laminin , in vivo , vascular endothelial growth factor , ischemia , biomedical engineering , materials science , microbiology and biotechnology , vegf receptors , cancer research , medicine , biology , extracellular matrix , botany
Itsuki Ajioka and co‐workers report a laminin‐sponge (purple) with affinity‐immobilized VEGF (yellow), which is an angiogenic growth factor. Neovascularization from existing blood vessels (red) in ischemic brain can potentially prevent the excess death of neurons (cyan) and improve functional recovery. The angiogenic activity of this sponge in vivo in a mouse stroke model is demonstrated in article number 1700183 .