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Tissue Engineering: Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling (Adv. Healthcare Mater. 11/2017)
Author(s) -
Sadeghi Amir Hossein,
Shin Su Ryon,
Deddens Janine C.,
Fratta Giuseppe,
Mandla Serena,
Yazdi Iman K.,
Prakash Gyan,
Antona Silvia,
Demarchi Danilo,
Buijsrogge Marc P.,
Sluijter Joost P. G.,
Hjortnaes Jesper,
Khademhosseini Ali
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201770054
Subject(s) - myofibroblast , tissue engineering , tissue remodeling , fibrosis , stimulation , microbiology and biotechnology , cancer research , medicine , biomedical engineering , pathology , biology , inflammation
Ali Khademhosseini and co‐workers describe an engineered 3D fibrotic heart tissue, which is created by fabricating physiologically relevant cardiac tissues with native‐like mechanical properties in article number 1601434 . Upon exogenous stimulation with profibrotic transforming growth factor beta‐1, these tissues reveal fibrogenic changes, such as collagen production, myofibroblast activation, and electrophysiological disturbances.