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Neural Stem Cells: A Dual Functional Scaffold Tethered with EGFR Antibody Promotes Neural Stem Cell Retention and Neuronal Differentiation for Spinal Cord Injury Repair (Adv. Healthcare Mater. 9/2017)
Author(s) -
Xu Bai,
Zhao Yannan,
Xiao Zhifeng,
Wang Bin,
Liang Hui,
Li Xing,
Fang Yongxiang,
Han Sufang,
Li Xiaoran,
Fan Caixia,
Dai Jianwu
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201770043
Subject(s) - neural stem cell , spinal cord injury , scaffold , microbiology and biotechnology , stem cell , spinal cord , neuroscience , cancer research , chemistry , medicine , biology , biomedical engineering
Jianwu Dai and co‐workers fabricate a dual functional collagen scaffold tethered with a collagen‐binding epidermal growth factor receptor (EGFR) antibody in article number 1601279 . This scaffold can simultaneously attract neural stem cells (NSCs) and promote their neuronal differentiation after spinal cord injury by specifically binding to EGFR molecule expressed on NSCs and attenuating EGFR signaling, which is responsible for the inhibition of differentiation of NSCs toward neurons.