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Oxidative Stress: Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles (Adv. Healthcare Mater. 5/2017)
Author(s) -
Olson Emilia S.,
Ortac Inanc,
Malone Christopher,
Esener Sadik,
Mattrey Robert
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201770026
Subject(s) - in vivo , oxidative stress , microbubbles , nanoparticle , ultrasound , oxidative phosphorylation , nanotechnology , materials science , biomedical engineering , chemistry , medicine , biochemistry , biology , radiology , microbiology and biotechnology
Inanc Ortac, Emilia S. Olson, Robert Mattrey, and co‐workers introduce an intravenously injectable probe labeling sites of oxidative injury in vivo in article number 1601163. The probe they develop is a nanoparticle platform enzymatically catalyzing H 2 O 2 to water and oxygen producing microbubbles detectable by a clinical ultrasound system. They demonstrate the functionality of 200 nm nanoparticles in vivo in rat ischemic renal injury (IRI) model.