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Drug Delivery: Zero‐Order Antibiotic Release from Multilayer Contact Lenses: Nonuniform Drug and Diffusivity Distributions Produce Constant‐Rate Drug Delivery (Adv. Healthcare Mater. 3/2017)
Author(s) -
Guzman Gustavo,
Eshaghi Siamak Shams,
Nugay Turgut,
Cakmak Mukerrem
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201770016
Subject(s) - drug delivery , drug , materials science , zero order , diffusion , contact lens , oxygen permeability , pharmacokinetics , biomedical engineering , nanotechnology , first order , pharmacology , chemistry , optics , oxygen , medicine , thermodynamics , physics , mathematics , organic chemistry
In article 1600775, Mukerrem Cakmak and co‐workers present a novel approach to zero‐order constant‐rate drug delivery from three‐layer bimodal amphiphilic conetwork contact lenses. Combined effects of nonuniform distribution of drug loading and diffusion constants maintains low local drug concentration at the lens–fluid interface and yields zero‐order drug delivery. The release rates of topical antibiotics provide constant‐rate therapeutic‐level delivery with appropriate oxygen permeability for at least 30 h.