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Conceptually Novel Black Phosphorus/Cellulose Hydrogels as Promising Photothermal Agents for Effective Cancer Therapy
Author(s) -
Xing Chenyang,
Chen Shiyou,
Qiu Meng,
Liang Xin,
Liu Quan,
Zou Qingshuang,
Li Zhongjun,
Xie Zhongjian,
Wang Dou,
Dong Biqin,
Liu Liping,
Fan Dianyuan,
Zhang Han
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701510
Subject(s) - photothermal therapy , self healing hydrogels , biocompatibility , materials science , black phosphorus , cellulose , nanotechnology , bacterial cellulose , natural polymers , photothermal effect , polymer , chemistry , composite material , polymer chemistry , organic chemistry , optoelectronics , metallurgy
Black phosphorus (BP) has recently emerged as an intriguing photothermal agent in photothermal therapy (PTT) against cancer by virtue of its high photothermal efficiency, biocompatibility, and biodegradability. However, naked BP is intrinsically characterized by easy oxidation (or natural degradation) and sedimentation inside the tumor microenvironment, leading to a short‐term therapeutic and inhomogeneous photothermal effect. Development of BP‐based nanocomposites for PTT against cancer therefore remains challenging. The present work demonstrates that green and injectable composite hydrogels based on cellulose and BP nanosheets (BPNSs) are of great efficiency for PTT against cancer. The resultant cellulose/BPNS‐based hydrogel possesses 3D networks with irregular micrometer‐sized pores and thin, strong cellulose‐formed walls and exhibits an excellent photothermal response, enhanced stability, and good flexibility. Importantly, this hydrogel nanoplatform is totally harmless and biocompatible both in vivo and in vitro. This work may facilitate the development of BP–polymer‐based photothermal agents in the form of hydrogels for biomedical‐related clinic applications.