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Polyphenol–Poloxamer Self‐Assembled Supramolecular Nanoparticles for Tumor NIRF/PET Imaging
Author(s) -
Wang Xinyu,
Yan Junjie,
Pan Donghui,
Yang Runlin,
Wang Lizhen,
Xu Yuping,
Sheng Jie,
Yue Yuanyuan,
Huang Qianhuan,
Wang Yanting,
Wang Rongrong,
Yang Min
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701505
Subject(s) - biocompatibility , supramolecular chemistry , poloxamer , nanoparticle , materials science , fluorescence lifetime imaging microscopy , in vivo , preclinical imaging , drug delivery , fluorescence , micelle , supramolecular assembly , biophysics , nanotechnology , chemistry , organic chemistry , polymer , aqueous solution , physics , microbiology and biotechnology , quantum mechanics , crystal structure , copolymer , biology
Self‐assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol and poloxamer self‐assemble supramolecular nanoparticles (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid and Pluronic F‐127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied in tumor near‐infrared fluorescence (NIRF) imaging and positron emission tomography (PET) imaging. With near‐infrared fluorescent dyes such as IR780 encapsulated via hydrophobic interactions, PPNPs are used in NIRF imaging. PPNPs with excess phenolic hydroxyl groups chelating positron emitting radionuclide 89 Zr function as a PET contrast agent. The in vivo results show surprisingly higher fluorescence intensity in tumors than in other tissues. In addition, PPNPs exhibit good biocompatibility in various cell lines and do not induce hemolysis in vitro. In this study, it is demonstrated that biodegradable and biocompatible PPNPs are an excellent bimodal contrast agent for in vivo tumor imaging.