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Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens
Author(s) -
Lakshminarayanan Rajamani,
Ye Enyi,
Young David James,
Li Zibiao,
Loh Xian Jun
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701400
Subject(s) - nanocarriers , antimicrobial , nanotechnology , solid lipid nanoparticle , liposome , nanoparticle , materials science , chemistry , organic chemistry
The rapid growth of harmful pathogens and their multidrug‐resistance poses a severe challenge for health professionals and for the development of new healthcare products. Various strategies are exploited for the development of effective antimicrobial agents, and nanoparticles are a particularly promising class of materials in this respect. This review summarizes recent advances in antimicrobial metallic, polymeric, and lipid‐based nanoparticles such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. The latter materials in particular are engineered for antimicrobial agent delivery and act by encapsulation, receptor‐based binding, and disruption of microbial adherence to cellular substrates. Potential strategies for the design of multifunctional antimicrobial nanocarriers, combining material chemistry and biological interface science, are also discussed.