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A Silk Cranial Fixation System for Neurosurgery
Author(s) -
Liu Keyin,
Shi Zhifeng,
Zhang Shaoqing,
Zhou Zhitao,
Sun Long,
Xu Tao,
Zhang Yeshun,
Zhang Guozheng,
Li Xinxin,
Chen Liang,
Mao Ying,
Tao Tiger H.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701359
Subject(s) - fixation (population genetics) , silk , neurosurgery , magnetic resonance imaging , tolerability , biomedical engineering , medicine , surgery , radiology , materials science , pathology , population , alternative medicine , environmental health , composite material
Cranial fixation should be safe, reliable, ideally degradable, and produce no hazardous residues and no artifacts on neuroimaging. Protein‐based fixation devices offer an exciting opportunity for this application. Here, the preclinical development and in vivo efficacy verification of a silk cranial fixation system in functional models are reported by addressing key challenges toward clinical use. A comprehensive study on this fixation system in rodent and canine animal models for up to 12 months is carried out. The silk fixation system shows a superb performance on the long‐term stability of the internal structural support for cranial flap fixation and bone reconnection and has good magnetic resonance imaging compatibility, and tolerability to high dose radiotherapy, underscoring the favorable clinical application of this system for neurosurgery compared to the current gold standard.