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Patient‐Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds
Author(s) -
Faramarzi Negar,
Yazdi Iman K.,
Nabavinia Mahboubeh,
Gemma Andrea,
Fanelli Adele,
Caizzone Andrea,
Ptaszek Leon M.,
Sinha Indranil,
Khademhosseini Ali,
Ruskin Jeremy N.,
Tamayol Ali
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701347
Subject(s) - 3d bioprinting , tissue engineering , self healing hydrogels , regenerative medicine , regeneration (biology) , biomedical engineering , materials science , stem cell , nanotechnology , microbiology and biotechnology , medicine , biology , polymer chemistry
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient‐specific biological factors for tissue engineering applications becomes more evident. Platelet‐rich plasma (PRP) is used as a patient‐specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs. PRP contains a cocktail of growth factors enhancing angiogenesis, stem cell recruitment, and tissue regeneration. Here, the development of an alginate‐based bioink that can be printed and crosslinked upon implantation through exposure to native calcium ions is reported. This platform can be used for the controlled release of PRP‐associated growth factors which may ultimately enhance vascularization and stem cell migration.