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Surface‐Enhanced Raman Scattering for Rapid Detection and Characterization of Antibiotic‐Resistant Bacteria
Author(s) -
Galvan Daniel D.,
Yu Qiuming
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701335
Subject(s) - nanotechnology , aptamer , bacteria , antibiotics , characterization (materials science) , biosensor , antibiotic resistance , raman scattering , materials science , microbiology and biotechnology , raman spectroscopy , biology , optics , physics , genetics
As the prevalence of antibiotic‐resistant bacteria continues to rise, biosensing technologies are needed to enable rapid diagnosis of bacterial infections. Furthermore, understanding the unique biochemistry of resistance mechanisms can facilitate the development of next generation therapeutics. Surface‐enhanced Raman scattering (SERS) offers a potential solution to real‐time diagnostic technologies, as well as a route to fundamental, mechanistic studies. In the current review, SERS‐based approaches to the detection and characterization of antibiotic‐resistant bacteria are covered. The commonly used nanomaterials (nanoparticles and nanostructured surfaces) and surface modifications (antibodies, aptamers, reporters, etc.) for SERS bacterial detection and differentiation are discussed first, and followed by a review of SERS‐based detection of antibiotic‐resistant bacteria from environmental/food processing and clinical sources. Antibiotic susceptibility testing and minimum inhibitory concentration testing with SERS are then summarized. Finally, recent developments of SERS‐based chemical imaging/mapping of bacteria are reviewed.