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Tropoelastin Implants That Accelerate Wound Repair
Author(s) -
Mithieux Suzanne M.,
AghaeiGharehBolagh Behnaz,
Yan Leping,
Kuppan Kekini V.,
Wang Yiwei,
GarcesSuarez Francia,
Li Zhe,
Maitz Peter K.,
Carter Elizabeth A.,
Limantoro Christina,
Chrzanowski Wojciech,
Cookson David,
RiboldiTunnicliffe Alan,
Baldock Clair,
Ohgo Kosuke,
Kumashiro Kristin K.,
Edwards Glenn,
Weiss Anthony S.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701206
Subject(s) - tropoelastin , wound healing , regeneration (biology) , biomedical engineering , resorption , implant , materials science , surgery , medicine , elastin , microbiology and biotechnology , pathology , biology
A novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat‐based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co‐treatment with full‐ and split‐thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point‐of‐care treatment of open wounds is provided.