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Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe 3 O 4 Nanoparticles for Theranostics In Vivo
Author(s) -
Zhou Ping,
Zhao Heng,
Wang Quan,
Zhou Zhiguo,
Wang Jing,
Deng Guang,
Wang Xiyou,
Liu Qian,
Yang Hong,
Yang Shiping
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701201
Subject(s) - in vivo , photoacoustic imaging in biomedicine , nanoparticle , materials science , peg ratio , hyperthermia , magnetic nanoparticles , nanomedicine , magnetic hyperthermia , nanotechnology , biomedical engineering , cancer research , nuclear magnetic resonance , medicine , biology , physics , microbiology and biotechnology , finance , optics , economics
Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe 3 O 4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting magnetic hyperthermia therapy in vivo. In the α v β 3 ‐positive U87MG glioblastoma xenograft model, the PA signal of RGD‐PEG‐MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2‐folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD‐PEG‐MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD‐PEG‐MNPs.