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MRI Visualization of Injectable Ureidopyrimidinone Hydrogelators by Supramolecular Contrast Agent Labeling
Author(s) -
Bakker Maarten H.,
Tseng Cheyenne C. S.,
Keizer Henk M.,
Seevinck Peter R.,
Janssen Henk M.,
Van Slochteren Frebus J.,
Chamuleau Steven A. J.,
Dankers Patricia Y. W.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701139
Subject(s) - self healing hydrogels , magnetic resonance imaging , in vivo , visualization , biomedical engineering , gadolinium , mri contrast agent , materials science , supramolecular chemistry , peg ratio , contrast (vision) , chemistry , computer science , medicine , radiology , polymer chemistry , biology , microbiology and biotechnology , finance , artificial intelligence , economics , crystal structure , metallurgy , crystallography
Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone‐based hydrogel (UPy‐PEG) is functionalized with a modified Gadolinium(III)‐DOTA complex (UPy‐Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high‐quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd‐labeled UPy‐PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.