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Excitation‐Dependent Theranostic Nanosheet for Cancer Treatment
Author(s) -
Guan Shanyue,
Yang Di,
Weng Yangziwan,
Lu Heng,
Meng Xiangmin,
Qu Xiaozhong,
Zhou Shuyun
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701123
Subject(s) - ruthenium , singlet oxygen , luminescence , supramolecular chemistry , nanosheet , materials science , photochemistry , irradiation , fluorescence , monolayer , hydroxide , excitation , photodynamic therapy , oxygen , nanotechnology , chemistry , crystallography , optoelectronics , catalysis , inorganic chemistry , organic chemistry , crystal structure , physics , engineering , quantum mechanics , nuclear physics , electrical engineering
In this work, a novel ruthenium complex loaded monolayer layered double hydroxide (LDH) (denoted as Ru(C‐bpy) 2 /mLDH) as supramolecular nanosensor is synthesized, which is greatly exclusive to the hypoxic tumor microenvironment. The Ru(C‐bpy) 2 /mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C‐bpy) 2 alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm. Moreover, the Ru(C‐bpy) 2 /mLDH is possessed of two‐photon fluorescence imaging ability under the 800 nm irradiation. In addition, the Ru(C‐bpy) 2 /mLDH can generate singlet oxygen with a high yield (φ ∆ ) of 0.28 under the 520 nm irradiation, while the φ ∆ of Ru(C‐bpy) 2 is 0.19. Therefore, the Ru(C‐bpy) 2 /mLDH can be applied as a supramolecular theranostic agent with light‐switchable cancer imaging and photodynamic therapy properties.