z-logo
Premium
Flexible Modulation of CO‐Release Using Various Nuclearity of Metal Carbonyl Clusters on Graphene Oxide for Stroke Remediation
Author(s) -
Tan Mein Jin,
Pan HanChi,
Tan Hui Ru,
Chai Jian Wei,
Lim Qi Feng,
Wong Ten It,
Zhou Xiaodong,
Hong ZiYao,
Liao LunDe,
Kong Kien Voon
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701113
Subject(s) - graphene , oxide , photothermal therapy , carbon monoxide , adsorption , ruthenium , materials science , photothermal effect , metal , photochemistry , chemical engineering , nanotechnology , chemistry , organic chemistry , catalysis , engineering , metallurgy
Utilizing the size‐dependent adsorption properties of ruthenium carbonyl clusters (Ru–carbon monoxide (CO)) onto graphene oxide (GO), a facile CO‐release platform for in situ vasodilation as a treatment for stroke‐related vascular diseases is developed. The rate and amount of formation of the CO‐release‐active Ru II (CO) 2 species can be modulated by a simple mixing procedure at room temperature. The subsequent thermally induced oxidation of Ru II (CO) 2 to RuO 2 on the GO surface results in the release of CO. Further modulation of thermal and CO‐release properties can be achieved via a hybridization of medium‐ and high‐nuclearity of Ru–CO clusters that produces a RuO 2 /Ru II (CO) 2 / 6 Ru–CO–GO composite, where 6 Ru–CO–GO provides a photothermally activated reservoir of Ru II (CO) 2 species and the combined infrared absorption properties of GO and RuO 2 provides photothermal response for in situ CO‐release. The RuO 2 /Ru II (CO) 2 / 6 Ru–CO–GO composite does not produce any cytotoxicity and the efficacy of the composite is further demonstrated in a cortical photothrombotic ischemia rat model.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here