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Tension‐Activated Delivery of Small Molecules and Proteins from Superhydrophobic Composites
Author(s) -
Wang Julia,
Colson Yolonda L.,
Grinstaff Mark W.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201701096
Subject(s) - coating , ultimate tensile strength , materials science , composite material , tension (geology) , fabrication , strain (injury) , tensile testing , drug delivery , nanotechnology , medicine , alternative medicine , pathology
The fabrication and performance of mechanically responsive multilayer superhydrophobic composites are reported. The application of tensile strain triggers the release of small molecules and proteins from these composites, with different tensile strain magnitudes and coating thickness influencing agent release. These mechanoresponsive composites consist of an absorbent drug core surrounded by an electrosprayed superhydrophobic protective coating that limits drug release in the absence of tensile strain. Coating thickness and applied tensile strain control release of chemotherapeutic cisplatin and enzyme β‐galactosidase, as measured by atomic absorption and UV–vis spectrophotometry, respectively, with preserved in vitro activity. Such mechanically responsive drug delivery devices, when coupled to existing dynamic mechanical forces in the body or integrated with mechanical medical devices, such as stents, will provide local controlled dosing.