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Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials
Author(s) -
Bruggeman Kiara F.,
Williams Richard J.,
Nisbet David R.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700836
Subject(s) - self healing hydrogels , tissue engineering , drug delivery , regenerative medicine , extracellular matrix , materials science , nanotechnology , regeneration (biology) , biomedical engineering , chemistry , engineering , polymer chemistry , microbiology and biotechnology , biochemistry , biology , cell
Tissue engineering scaffolds are designed to mimic physical, chemical, and biological features of the extracellular matrix, thereby providing a constant support that is crucial to improved regenerative medicine outcomes. Beyond mechanical and structural support, the next generation of these materials must also consider the more dynamic presentation and delivery of drugs or growth factors to guide new and regenerating tissue development. These two aspects are explored expansively separately, but they must interact synergistically to achieve optimal regeneration. This review explores common tissue engineering materials types, electrospun polymers and hydrogels, and strategies used for incorporating drug delivery systems into these scaffolds.