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Cell‐Based Drug Delivery and Use of Nano‐and Microcarriers for Cell Functionalization
Author(s) -
Timin Alexander S.,
Litvak Maxim M.,
Gorin Dmitry A.,
AtochinaVasserman Ele.,
Atochin Dmitriy N.,
Sukhorukov Gleb B.
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700818
Subject(s) - microcarrier , nanomedicine , drug delivery , surface modification , nanotechnology , internalization , targeted drug delivery , drug , cell , materials science , chemistry , pharmacology , medicine , nanoparticle , biochemistry
Cell functionalization with recently developed various nano‐ and microcarriers for therapeutics has significantly expanded the application of cell therapy and targeted drug delivery for the effective treatment of a number of diseases. The aim of this progress report is to review the most recent advances in cell‐based drug vehicles designed as biological transporter platforms for the targeted delivery of different drugs. For the design of cell‐based drug vehicles, different pathways of cell functionalization, such as covalent and noncovalent surface modifications, internalization of carriers are considered in greater detail together with approaches for cell visualization in vivo. In addition, several animal models for the study of cell‐assisted drug delivery are discussed. Finally, possible future developments and applications of cell‐assisted drug vehicles toward targeted transport of drugs to a designated location with no or minimal immune response and toxicity are addressed in light of new pathways in the field of nanomedicine.